Luecke R H, Wosilait W D, Young J F
Department of Chemical Engineering, University of Missouri-Columbia 65211, USA.
Int J Biomed Comput. 1995 Jun;39(3):337-47. doi: 10.1016/0020-7101(95)01115-u.
During human pregnancy, there is a huge increase in the total weight of the embryo/fetus from conception to term. The total growth, which is the summation of growth of the various organs and tissues that make up the organism, was analyzed in a previous paper and fitted to the Gompertz equation for growth. In the present study, allometry, the quantitative representation of the consequence of size, was utilized to describe the correlation of individual fetal organ/tissue weights with the total fetal weight. The organ/tissue weight and the total fetal weight data used in the analyses were pooled from various sources that provided data ranging from 25 days to 300 days post-conception. Allometric equations are presented for 16 embryo/fetal organs and tissues. The standard allometric equation gave adequate fits for embryo/fetal adrenal, bone, bone marrow, brain, heart, liver, pancreas, plasma, skeletal muscle, extracellular water, thymus and thyroid; but it was necessary to use a quadratic form of the allometric equation for embryo/fetal fat, kidney, lung and spleen. Parameters were also calculated for crown-to-rump and crown-to-heels for fetal lengths that occur during pregnancy.
在人类妊娠期间，从受孕到足月，胚胎/胎儿的总体重会大幅增加。总体生长是构成生物体的各种器官和组织生长的总和，在之前的一篇论文中已对其进行分析，并拟合到生长的Gompertz方程。在本研究中，异速生长（即大小结果的定量表示）被用于描述单个胎儿器官/组织重量与胎儿总体重之间的相关性。分析中使用的器官/组织重量和胎儿总体重数据来自各种来源，这些来源提供了受孕后25天至300天的数据。文中给出了16种胚胎/胎儿器官和组织的异速生长方程。标准异速生长方程对胚胎/胎儿的肾上腺、骨骼、骨髓、脑、心脏、肝脏、胰腺、血浆、骨骼肌、细胞外液、胸腺和甲状腺拟合良好；但对于胚胎/胎儿的脂肪、肾脏、肺和脾脏，则需要使用异速生长方程的二次形式。还计算了孕期胎儿身长从头顶至臀长和头顶至足跟的参数。
