膦丝菌素，一种由糖丝菌属ST-888菌株产生的新型除草抗生素。II. 结构测定。
Phosphonothrixin, a novel herbicidal antibiotic produced by Saccharothrix sp. ST-888. II. Structure determination.
作者信息
Kimura T, Nakamura K, Takahashi E
机构信息
Nishiki Research Laboratories, Kureha Chemical Industry Co., Ltd., Fukushima, Japan.
出版信息
J Antibiot (Tokyo). 1995 Oct;48(10):1130-3. doi: 10.7164/antibiotics.48.1130.
PMID:7490219
Abstract
Phosphonothrixin (1) is a novel herbicidal agent produced by Saccharothrix sp. ST-888. This unique compound possessing a C-P bond and an isoprene unit was determined to be 2-hydroxy-2-hydroxymethyl-3-oxobutyl-phosphonic acid. Unusually rapid proton-deuterium (H-D) exchange of the methyl ketone unit of this antibiotic in D2O solution was observed. Phosphonothrixin can be classified as a new type of natural product herbicide having a C-P bond in the molecule.
摘要
膦丝菌素（1）是由糖丝菌属ST - 888菌株产生的一种新型除草剂。这种具有碳 - 磷键和异戊二烯单元的独特化合物被确定为2 - 羟基 - 2 - 羟甲基 - 3 - 氧代丁基膦酸。在重水溶液中观察到这种抗生素的甲基酮单元存在异常快速的质子 - 氘（H - D）交换。膦丝菌素可被归类为一种分子中含有碳 - 磷键的新型天然产物除草剂。
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