寻常型白癜风自体微小皮片移植后的色素再生：19例患者的结果

Repigmentation in vitiligo vulgaris by autologous minigrafting: results in nineteen patients.

作者信息

Boersma B R, Westerhof W, Bos J D

机构信息

Department of Dermatology, Academic Medical Center, University of Amsterdam, The Netherlands.

出版信息

J Am Acad Dermatol. 1995 Dec;33(6):990-5. doi: 10.1016/0190-9622(95)90292-9.

DOI:10.1016/0190-9622(95)90292-9

PMID:7490371

Abstract

BACKGROUND

Minigrafting is a successful therapy for localized vitiligo but has never been reported for vitiligo vulgaris.

OBJECTIVE

Our purpose was to evaluate the efficacy of minigrafting in vitiligo vulgaris.

METHODS

In 59 patients with stable vitiligo vulgaris, a minigraft test was done by implanting two minigrafts in the lesion to be grafted. Patients were selected for grafting when spread of pigment was observed within 3 months. The rate of repigmentation was evaluated by digital image analysis.

RESULTS

Twenty-three patients (36 lesions), of 24 with a positive minigraft test, were grafted. The results of 19 patients were analyzed, showing 80% to 99% repigmentation in 14 lesions, 50% to 80% repigmentation in 10 lesions, and zero to 50% repigmentation in 12 lesions. Time of observation varied from 3 to 12 months after grafting. Best results were observed after 9 to 12 months. In all patients with a positive Koebner phenomenon depigmentation of the minigrafts developed.

CONCLUSION

Autologous minigrafting is an effective therapy for stable vitiligo vulgaris in a selected group of patients.

摘要

背景

微小皮片移植是局限性白癜风的一种成功治疗方法，但寻常型白癜风的微小皮片移植从未见报道。

目的

我们的目的是评估微小皮片移植治疗寻常型白癜风的疗效。

方法

对59例稳定期寻常型白癜风患者，通过在待移植皮损处植入两片微小皮片进行微小皮片移植试验。当在3个月内观察到色素扩散时，选择患者进行移植。通过数字图像分析评估色素恢复率。

结果

24例微小皮片移植试验阳性患者中的23例（36处皮损）进行了移植。分析了19例患者的结果，显示14处皮损色素恢复率为80%至99%，10处皮损色素恢复率为50%至80%，12处皮损色素恢复率为0至50%。观察时间为移植后3至12个月。9至12个月后观察到最佳效果。所有同形反应阳性的患者，微小皮片均出现色素脱失。