Falabella R, Arrunategui A, Barona M I, Alzate A
Department of Internal Medicine, Fundacion Valle del Lili, Cali, Columbia.
J Am Acad Dermatol. 1995 Feb;32(2 Pt 1):228-32. doi: 10.1016/0190-9622(95)90131-0.
Selected patients with stable and refractory vitiligo may consider melanocyte transplantation as a therapeutic alternative. A method to anticipate the response to surgical repair is not available.
We evaluated the pigment spread of minigrafts when implanted within achromic lesions of stable vitiligo as a test to identify good candidates for surgical repigmentation.
Four to six minigrafts of 1.0 to 1.2 mm were implanted within lesions of patients with unilateral (localized) and bilateral (generalized) vitiligo. Pigment spread was assessed 3 months later.
Forty-seven subjects were examined. In unilateral vitiligo 19 of 20 patients (95%) had a positive test result in comparison with only 13 of 27 patients (48%) with bilateral vitiligo (p = 0.002).
The minigrafting test is a reliable tool to identify patients with stable vitiligo who may respond to melanocyte transplantation. Unilateral (localized) vitiligo is the best indication for surgical repigmentation.
部分稳定型和难治型白癜风患者可考虑将黑素细胞移植作为一种治疗选择。目前尚无预测手术修复效果的方法。
我们评估了微小皮片移植至稳定期白癜风无色素皮损后的色素扩散情况，以此作为筛选手术复色良好候选者的一项检测。
将4至6片1.0至1.2毫米的微小皮片移植到单侧（局限性）和双侧（泛发性）白癜风患者的皮损内。3个月后评估色素扩散情况。
共检查了47名受试者。单侧白癜风患者中，20例有19例（95%）检测结果为阳性，而双侧白癜风患者中27例仅有13例（48%）检测结果为阳性（p = 0.002）。
微小皮片移植检测是一种可靠的工具，可用于识别可能对黑素细胞移植有反应的稳定期白癜风患者。单侧（局限性）白癜风是手术复色的最佳适应证。
