Bush L M, Calmon J, Johnson C C
JFK Medical Center, West Palm Beach, Florida, USA.
Infect Dis Clin North Am. 1995 Sep;9(3):653-86.
Penicillins continue to be essential antibiotics for the treatment and prophylaxis of many infectious diseases. Recent advances have resulted in compounds with favorable new antimicrobial and pharmacologic properties. This article reviews the spectrum of activity, toxicity, pharmacokinetics, and clinical uses of the extended spectrum penicillins and the beta-lactamase inhibitor combination agents.
青霉素仍然是治疗和预防许多传染病的重要抗生素。最近的进展产生了具有良好新抗菌和药理学特性的化合物。本文综述了广谱青霉素和β-内酰胺酶抑制剂联合制剂的抗菌谱、毒性、药代动力学及临床应用。
