Bush L M, Johnson C C
Division of Infectious Diseases, John F. Kennedy Memorial Medical Center, West Palm Beach, Florida, USA.
Infect Dis Clin North Am. 2000 Jun;14(2):409-33, ix. doi: 10.1016/s0891-5520(05)70255-5.
Although research and development of new penicillins have declined, penicillins continue to be essential antibiotics for the treatment and prophylaxis of infectious diseases. The most recent additions are the ureidopenicillins and beta-lactam/beta-lactamase inhibitor combinations. This article reviews the spectrum of activity, toxicity, pharmacokinetics, and clinical uses of the ureidopenicillins, and the beta-lactam/beta-lactamase inhibitor combination agents.
尽管新型青霉素的研发有所减少，但青霉素仍然是治疗和预防传染病的重要抗生素。最新增加的品种是脲基青霉素和β-内酰胺/β-内酰胺酶抑制剂组合。本文综述了脲基青霉素以及β-内酰胺/β-内酰胺酶抑制剂组合药物的抗菌谱、毒性、药代动力学和临床应用。
