Frank M O, Mandell G L
Indiana University School of Medicine, Indianapolis, USA.
Infect Dis Clin North Am. 1995 Sep;9(3):769-81.
Strategies of augmenting or attenuating the immune system's response to infection are promising potential methods to enhance antibacterial therapy. Many of these new therapies are natural cytokines, such as the hematopoietic growth factors and interferons, which upregulate the immune response. Other examples include replacement therapies, such as immune globulin, and downregulators of the immune response, such as corticosteroids. In the near future it may be possible to adjust the host response to microbial infection to maximally inhibit the microbe while minimizing inflammatory damage.
增强或减弱免疫系统对感染反应的策略是有望增强抗菌治疗效果的潜在方法。许多这类新疗法是天然细胞因子，如造血生长因子和干扰素，它们可上调免疫反应。其他例子包括替代疗法，如免疫球蛋白，以及免疫反应下调剂，如皮质类固醇。在不久的将来，有可能调整宿主对微生物感染的反应，以最大程度地抑制微生物，同时将炎症损伤降至最低。
