Loiseau H, Pedespan J M, Vital A, Marchal C, Vital C, Cohadon F
University Clinic of Neurosurgery, Hôpital Pellegrin, Bordeaux, France.
J Neurosurg. 1995 Dec;83(6):1075-9. doi: 10.3171/jns.1995.83.6.1075.
A rare case of lymphoplasmacyte-rich meningioma observed in a young girl is reported. The first clinical manifestations of the disease were seizures. Neuroradiological images favored the existence of a meningioma. Abnormalities in the patient's blood chemistry, principally including hypergammaglobulinemia and inflammatory syndrome, were associated with the disease. The tumor was histologically confirmed as meningioma with massive infiltrates of type B lymphocytes. The pathophysiology of the conspicuous lymphoplasmacyte infiltrates, responsible for peripheral blood abnormalities, has remained poorly understood. Alternative diagnostic hypotheses of masses that mimic this type of meningioma are discussed.
报告了一例在年轻女孩中观察到的富含淋巴浆细胞的脑膜瘤罕见病例。该疾病的首发临床表现为癫痫发作。神经放射学影像显示支持脑膜瘤的存在。患者血液化学异常，主要包括高球蛋白血症和炎症综合征，与该疾病相关。肿瘤经组织学确诊为脑膜瘤，伴有大量B淋巴细胞浸润。导致外周血异常的显著淋巴浆细胞浸润的病理生理学仍了解甚少。文中讨论了模仿此类脑膜瘤的肿块的其他诊断假说。
