Gutiérrez Morales Julio César, Gutiérrez Morales Sandra Eugenia, Astudillo González Aurora
Department of Neurosurgery, Hospital Universitario Central de Asturias, Oviedo, Spain.
Brain Pathol. 2009 Apr;19(2):347-8. doi: 10.1111/j.1750-3639.2009.00280.x.
Metastasis of an extracranial malignant neoplasm to a meningioma is a rare event.We report a case of a 72-year-old man who presented abruptly with a grand mal seizure. Neuroradiological examination revealed an extraaxial lesion located in the posterior right frontal convexity with poorly defined boundaries. Histological and immunohistochemical examination showed that the lesion was a meningothelial meningioma harboring metastatic renal cell carcinoma.The MRI could be indicative but not specific of this type of lesion.Some cases of intracranial meningiomas containing metastatic carcinomas have been published, but to our knowledge only five cases of renal cell carcinoma metastasizing to a meningioma have been reported. Possible explanations for this type of "tumor in tumor" lesion are reviewed.
颅外恶性肿瘤转移至脑膜瘤是一种罕见的情况。我们报告一例72岁男性，该患者突然出现大发作癫痫。神经放射学检查显示在右额后凸有一个边界不清的轴外病变。组织学和免疫组化检查表明该病变是一个含有转移性肾细胞癌的脑膜内皮型脑膜瘤。MRI对这类病变可能具有指示性，但不具有特异性。已有一些颅内脑膜瘤合并转移癌的病例报道，但据我们所知，仅有5例肾细胞癌转移至脑膜瘤的病例被报道。本文对这种“瘤中瘤”病变的可能解释进行了综述。
