Kirsch R
Res Vet Sci. 1978 Nov;25(3):263-5.
The in vitro ovicidal activity of fenbendazole against eggs of Ostertagia ostertagi, Haemonchus contortus and Trichostrongylus colubriformis was observed using different concentrations of active principle. The optimum concentration for ovicidal activity is evidently 0.5 ppm fenbendazole. A further increase in concentration results in a decrease in activity which is probably due to physical causes. Ovicidal activity of the product is assessed by the proportion of non embryonated eggs as well as embryonated eggs which are not capable of hatching. By this method of evaluation a higher ovicidal activity is recorded. Ten h after treating sheep with fenbendazole (dose 5 mg/kg) a large number of eggs whose development was inhibited, as well as atypical eggs were detectable in the faeces. Twelve h after treatment, the capacity for development of the eggs was largely suppressed.
使用不同浓度的活性成分观察了芬苯达唑对奥斯特他线虫、捻转血矛线虫和蛇形毛圆线虫虫卵的体外杀卵活性。杀卵活性的最佳浓度显然是0.5 ppm的芬苯达唑。浓度进一步增加会导致活性降低，这可能是由物理原因造成的。该产品的杀卵活性通过未受精卵以及不能孵化的受精卵的比例来评估。通过这种评估方法记录到了更高的杀卵活性。用芬苯达唑（剂量5 mg/kg）治疗绵羊10小时后，在粪便中可检测到大量发育受到抑制的虫卵以及非典型虫卵。治疗12小时后，虫卵的发育能力被大大抑制。
