Kolettis P N, Stowe N T, Inman S R, Thomas A J
Department of Urology, Cleveland Clinic Foundation, Ohio 44195, USA.
J Urol. 1996 Jan;155(1):350-4.
The purpose of this study was to characterize the hemodynamic changes in the contralateral testis during acute spermatic cord torsion in anesthetized rats.
We used videomicroscopy to examine the microcirculation of the contralateral testis following acute torsion. Specifically, we examined the effect on vasomotion, a rhythmic dilation and constriction of the arterioles that is involved in fluid and nutrient exchange and modulation of local vascular resistance. In a separate set of experiments, blood flow in the contralateral internal spermatic artery was measured with an ultrasonic flow probe during acute torsion.
Following 720 degrees torsion, the amplitude of vasomotion in the contralateral testis increased 121% (29.0 +/- 3.9% versus 13.0 +/- 1.7%) compared with controls. Blood flow in the contralateral internal spermatic artery decreased 43% after 2 hours' torsion.
Acute spermatic cord torsion altered the microcirculation by increasing the amplitude of vasomotion and decreased total blood flow to the opposite testis. Because the hydraulic resistance of a blood vessel exhibiting vasomotion is always less than a vessel with the same average but static diameter, the observed microcirculatory changes may be an adaptive response to preserve local flow in the presence of decreased total flow. The long-term consequences of these changes in the microcirculation may affect testicular function and ultimately fertility.
本研究旨在描述麻醉大鼠急性精索扭转时对侧睾丸的血流动力学变化。
我们使用视频显微镜检查急性扭转后对侧睾丸的微循环。具体而言，我们研究了其对血管运动的影响，血管运动是小动脉的一种有节奏的扩张和收缩，参与液体和营养物质交换以及局部血管阻力的调节。在另一组实验中，在急性扭转期间用超声血流探头测量对侧精索内动脉的血流。
扭转720度后，与对照组相比，对侧睾丸血管运动的幅度增加了121%（从13.0±1.7%增至29.0±3.9%）。扭转2小时后，对侧精索内动脉的血流减少了43%。
急性精索扭转通过增加血管运动幅度改变了微循环，并减少了对侧睾丸的总血流量。由于表现出血管运动的血管的水力阻力总是小于具有相同平均直径但静止的血管，观察到的微循环变化可能是在总血流量减少的情况下维持局部血流的一种适应性反应。这些微循环变化的长期后果可能会影响睾丸功能并最终影响生育能力。
