Becker E J, Turner T T
Department of Urology, University of Virginia School of Medicine, Charlottesville 22908, USA.
J Androl. 1995 Jul-Aug;16(4):342-51.
Previous studies of experimental torsion have suggested that there may be important differences between the adult testis and the prepubertal testis in their responses to torsion, especially with regard to the potential for contralateral damage following unilateral testicular torsion. In the present study, adult Sprague-Dawley rats and prepubertal Sprague-Dawley rats (35 days of age) were subjected to unilateral 1-, 2-, and 4-hour periods of 720 degrees or 360 degrees testicular torsion. Ipsilateral and contralateral testes were examined 30 and 60 days after torsion repair for effects on testis weight, histology, and daily sperm production (DSP). Other animals were subjected to 1-/or 4-hour 720 degrees torsion, and testicular vein testosterone concentrations were determined 30 days later. In adult animals, 1-, 2-, and 4-hour 720 degrees torsion resulted in a significant decline in ipsilateral testis weight within 30 days. Endocrine and exocrine function were also clearly disrupted. In prepubertal animals, 1-hour 720 degrees torsion significantly reduced testis weight 60 days after surgery. Also, prepubertal DSP values and testicular vein testosterone concentrations were not significantly reduced from control values by 1-hour 720 degrees torsion when examined 30 days after surgery. Longer periods of 720 degrees torsion resulted in damage similar to that seen in the adult animals. Neither adult nor prepubertal animals regained any lost function when examined 60 days after insult. Torsion of 360 degrees induced no testicular injury in adult or prepubertal animals. Contralateral testes were not affected by degree or duration of torsion in either adult or prepubertal animals. These results suggest that the prepubertal testis may be more refractory to the effects of short periods of torsion than the adult. More importantly, these results demonstrate that ipsilateral torsion does not result in contralateral testicular damage in either adult or prepubertal animals.
以往关于实验性睾丸扭转的研究表明，成年睾丸和青春期前睾丸在对扭转的反应上可能存在重要差异，尤其是在单侧睾丸扭转后对侧损伤的可能性方面。在本研究中，对成年斯普拉格 - 道利大鼠和青春期前斯普拉格 - 道利大鼠（35日龄）进行单侧720度或360度、时长1小时、2小时和4小时的睾丸扭转。在扭转修复后30天和60天检查同侧和对侧睾丸，观察对睾丸重量、组织学和每日精子生成量（DSP）的影响。其他动物进行1小时或4小时720度扭转，30天后测定睾丸静脉睾酮浓度。在成年动物中，1小时、2小时和4小时720度扭转导致30天内同侧睾丸重量显著下降。内分泌和外分泌功能也明显受到干扰。在青春期前动物中，1小时720度扭转使术后60天的睾丸重量显著降低。此外，术后30天检查时，1小时720度扭转并未使青春期前的DSP值和睾丸静脉睾酮浓度相对于对照值显著降低。更长时间的720度扭转导致的损伤与成年动物相似。在损伤后60天检查时，成年和青春期前动物均未恢复任何丧失的功能。360度扭转在成年或青春期前动物中均未引起睾丸损伤。在成年或青春期前动物中，对侧睾丸均未受到扭转程度或持续时间的影响。这些结果表明，青春期前睾丸可能比成年睾丸对短时间扭转的影响更具耐受性。更重要的是，这些结果表明，同侧扭转在成年或青春期前动物中均不会导致对侧睾丸损伤。
