Dragomirescu M, Novac E, Marţincu V, Olaru G, Stănescu-Lupu D, Voiculescu D
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1978 Oct-Dec;23(4):193-200.
Retrospective analysis of the tetanus cases, admitted over a six year period, shows the high risks involved by the insufficient immunoprotection. The failure of emergency immunization, with its effects on the incidence and evolution of the disease, may be accounted for by : the difficulty in establishing the vaccination past history, probable decrease of protection with time due to basal immunization, inconstant response to the booster dose, immunodepressive side effects, the drawbacks of antitoxic serum. With reference to their own experience and the published data concerning the methods applied for obtaining a more rapid response to anatoxin and possible optimizing of the protective titre concurrent with the incubation period of tetanus. Experimental investigations have demonstrated the superiority of repeated, multifocal inoculations for obtaining an earlier antitoxic immunity.
对六年期间收治的破伤风病例进行回顾性分析表明，免疫保护不足会带来高风险。应急免疫失败及其对疾病发病率和病程的影响，可能是由于：难以确定既往接种史、基础免疫后随着时间推移保护作用可能下降、对加强剂量的反应不稳定、免疫抑制副作用、抗毒素血清的缺点。参照他们自己的经验以及已发表的有关为更快获得抗毒素反应和在破伤风潜伏期同时可能优化保护效价所采用方法的数据。实验研究已证明，重复、多部位接种在获得更早抗毒素免疫方面具有优越性。
