Sutton P, Moreland A, Hutchinson I V, Müllbacher A
Division of Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Act Australia.
Transplantation. 1995 Nov 15;60(9):900-2.
Gliotoxin is an immunosuppressive secondary metabolite produced by several pathogenic fungi. It has previously been shown to prevent graft-versus-host disease in transplantation of allogeneic mouse bone marrow and to reduce the immunogenicity of human fetal pancreas. We here report on the effect of gliotoxin on the prevention of rejection of allografts in two distinct models. Bathing mouse thyroid tissue in gliotoxin solution for 16 hr prolonged graft survival following transplantation into allogeneic recipients. In contrast the perfusion of rat kidneys with gliotoxin followed by 1 hr of incubation before orthotopic transplantation had little success with preventing allograft rejection. This disparity is most likely due to the incubation in the renal model not allowing sufficient time for the elimination of antigen presenting cells in the donor organ. However, the success with the thyroid grafts demonstrates the potential of gliotoxin as an immunomodulating agent in organ transplantation and warrants further investigation in other systems.
Gliotoxin是几种致病真菌产生的一种免疫抑制性次生代谢产物。先前已证明它能预防同种异体小鼠骨髓移植中的移植物抗宿主病，并降低人胎儿胰腺的免疫原性。我们在此报告Gliotoxin在两种不同模型中预防同种异体移植排斥反应的效果。将小鼠甲状腺组织在Gliotoxin溶液中浸泡16小时可延长移植到同种异体受体后的移植物存活时间。相比之下，在大鼠肾脏原位移植前用Gliotoxin灌注并孵育1小时，在预防同种异体移植排斥方面收效甚微。这种差异很可能是由于肾脏模型中的孵育时间不足以让供体器官中的抗原呈递细胞被清除。然而，甲状腺移植的成功证明了Gliotoxin作为器官移植免疫调节剂的潜力，值得在其他系统中进一步研究。
