Gregersen H, Drewes A M, Asschenfeldt P B, Laursen J C
Medicinsk-haematologisk afdeling og patologisk institut, Aalborg Sygehus.
Ugeskr Laeger. 1995 Nov 6;157(45):6274-5.
A patient with chronic lymphocytic leukemia (CLL) treated with chlorambucil and prednisone developed chronic myelocytic leukemia (CML) five years later. An association between the two chronic leukemias has only rarely been reported. In the majority of cases the CLL preceded CML after which the malignancies coexisted morphologically in bone marrow and peripheral blood. In this case we report a suppression of CLL related symptoms and blood findings after the emergence of CML. However, immunophenotypic studies demonstrated a minor remaining population of CLL cells in the peripheral blood.
一名接受苯丁酸氮芥和泼尼松治疗的慢性淋巴细胞白血病（CLL）患者五年后发展为慢性粒细胞白血病（CML）。两种慢性白血病之间的关联鲜有报道。在大多数病例中，CLL先于CML出现，之后两种恶性肿瘤在骨髓和外周血中形态学上共存。在本病例中，我们报告了CML出现后CLL相关症状和血液检查结果受到抑制。然而，免疫表型研究显示外周血中仍残留少量CLL细胞。
