Delmée M, Warny M
Unité de Microbiologie, UCL, Bruxelles, Belgium.
Acta Gastroenterol Belg. 1995 May-Aug;58(3-4):313-7.
Clostridium difficile is the main etiological agent of antibiotic associated diarrhoea and pseudomembranous colitis (PMC). It is considered as the most frequent agent of infectious diarrhoea occurring in hospitalized patients, in whom it is responsible for a high morbidity and occasional mortality even when the diagnosis and the treatment are pursued aggressively (1). The pathology is due to the production of at least two toxins: toxin A is an enterotoxin which induces intestinal tissue damage and a fluid response and toxin B is a cytotoxin which lacks any enterotoxic activity but is believed to exert an additive effect in vivo (2).
艰难梭菌是抗生素相关性腹泻和伪膜性结肠炎（PMC）的主要病原体。它被认为是住院患者中最常见的感染性腹泻病原体，即使积极进行诊断和治疗，它仍会导致高发病率和偶发性死亡（1）。其病理原因是产生至少两种毒素：毒素A是一种肠毒素，可诱导肠道组织损伤和液体反应；毒素B是一种细胞毒素，缺乏任何肠毒素活性，但被认为在体内发挥累加效应（2）。
