Delmée M, Melin P, Peetermans W, Verbist L, Verschraegen G
Université Catholique de Louvain, Unité de Microbiologie, Bruxelles.
Acta Clin Belg. 1995;50(2):114-6. doi: 10.1080/17843286.1995.11718431.
Due to the growing incidence and the severity of infections due to vancomycin resistant enterococci, it is now recommended to treat mild to moderate cases of Clostridium difficile-associated diarrhoea with metronidazole while maintaining the use of oral vancomycin in serious or life-threatening colitis. Clostridium difficile is a common cause of diarrhoea after antibiotic therapy and induces a spectrum of diseases ranging from mild diarrhoea to pseudomembranous colitis (PMC). It is considered to be the first cause of diarrhoea occurring among hospitalized patients (1).
由于耐万古霉素肠球菌引起的感染发病率不断上升且病情愈发严重,目前建议使用甲硝唑治疗轻度至中度艰难梭菌相关性腹泻病例,而对于严重或危及生命的结肠炎则继续使用口服万古霉素。艰难梭菌是抗生素治疗后腹泻的常见原因,可引发一系列疾病,从轻度腹泻到假膜性结肠炎(PMC)。它被认为是住院患者腹泻的首要原因(1)。