Lehel J, Laczay P, Móra Z, Semjén G
Department of Pharmacology and Toxicology, University of Veterinary Science, Budapest, Hungary.
Acta Vet Hung. 1995;43(2-3):321-33.
The tolerance of chickens to monensin (12.5 mg/kg of feed) and maduramicin (3.0 mg/kg of feed) fed at a reduced dose in the presence of the antioxidant duokvin was studied in two experiments including 2 x 200 Tetra-82 broiler chickens. Tolerance was assessed by the appearance of clinical signs indicative of a toxic effect, the number of deaths, the groups' body weight gain, feed and drinking water intake, the aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) activities, calcium ion, inorganic phosphate and total protein content of the blood plasma, the haematocrit value, and haemoglobin concentration. When applied at a dose that had proved to be optimum in the efficacy studies, neither the monensin-duokvin combination (12.5 mg monensin per kg of feed + 120 mg duokvin per kg of feed) nor the maduramicin-duokvin combination (3.0 mg maduramicin per kg of feed + 120 mg duokvin per kg of feed) exerted a statistically significant influence on the parameters tested.
在两项实验中，对2×200只Tetra - 82肉鸡进行研究，以考察在抗氧化剂多维喹存在的情况下，鸡对以降低剂量投喂的莫能菌素（每千克饲料12.5毫克）和马杜霉素（每千克饲料3.0毫克）的耐受性。通过出现表明有毒效应的临床症状、死亡数量、各组体重增加情况、饲料和饮水摄入量、天冬氨酸转氨酶（AST）和乳酸脱氢酶（LDH）活性、血浆中钙离子、无机磷酸盐和总蛋白含量、血细胞比容值以及血红蛋白浓度来评估耐受性。当以在功效研究中已证明为最佳的剂量应用时，莫能菌素 - 多维喹组合（每千克饲料12.5毫克莫能菌素 + 每千克饲料120毫克多维喹）和马杜霉素 - 多维喹组合（每千克饲料3.0毫克马杜霉素 + 每千克饲料120毫克多维喹）对所测试的参数均未产生统计学上的显著影响。
