Chen X, McCullagh P
Developmental Physiology Group, John Curtin School of Medical Research, Australian National University, Canberra.
J Autoimmun. 1995 Aug;8(4):521-38. doi: 10.1016/0896-8411(95)90006-3.
Lymph node cells from DA rats that had been exposed in utero to 131I in doses sufficient to interrupt thyroid development, attacked monolayers of normal syngeneic thyrocytes in vitro. Lymph node cells from normal DA rats did not damage syngeneic thyrocyte monolayers. Thyrocytes could be protected from damage provided they had been incubated with lymph node cells from normal syngeneic rats before the introduction of lymph node cells from 131I exposed rats. Spleen cells from both 131I exposed and normal rats attacked syngeneic thyrocytes. It is concluded that normal rats possess cells capable of downregulating anti-thyroid autoimmunity.
在子宫内暴露于足以干扰甲状腺发育剂量的131I的DA大鼠的淋巴结细胞，在体外攻击正常同基因甲状腺细胞单层。正常DA大鼠的淋巴结细胞不会损伤同基因甲状腺细胞单层。如果在引入来自暴露于131I的大鼠的淋巴结细胞之前，将甲状腺细胞与来自正常同基因大鼠的淋巴结细胞一起孵育，则可以保护甲状腺细胞免受损伤。来自暴露于131I的大鼠和正常大鼠的脾细胞都会攻击同基因甲状腺细胞。得出的结论是，正常大鼠拥有能够下调抗甲状腺自身免疫的细胞。
