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与正常伙伴联体共生后自身免疫的减弱

Curtailment of autoimmunity following parabiosis with a normal partner.

作者信息

McCullagh P

机构信息

John Curtin School of Medical Research, Australian National University, Canberra.

出版信息

Immunology. 1990 Dec;71(4):595-7.

PMID:2279743
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1384885/
Abstract

The development of thyroiditis in DA rats that had been exposed to 131I in utero was prevented by parabiosis to normal, syngeneic partners. However, if the normal partner had received sublethal irradiation before parabiosis, thyroid implants placed in either partner were likely to manifest spontaneous thyroiditis.

摘要

在子宫内暴露于131I的DA大鼠中，通过与正常同基因伙伴联体共生可预防甲状腺炎的发生。然而，如果正常伙伴在联体共生前接受了亚致死剂量的照射，那么在任一伙伴体内植入的甲状腺都有可能出现自发性甲状腺炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5cc/1384885/0b9f79960ac4/immunology00127-0139-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5cc/1384885/0b9f79960ac4/immunology00127-0139-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5cc/1384885/0b9f79960ac4/immunology00127-0139-a.jpg

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本文引用的文献

1
On the mechanism of immunologic self recognition.关于免疫自我识别的机制。
J Immunol. 1962 Oct;89:505-10.
2
Anti-idiotypic immunity and autoimmunity. I. In vitro and in vivo effects of anti-idiotypic antibodies to spontaneously occurring autoantibodies to rat thyroglobulin.抗独特型免疫与自身免疫。I. 针对大鼠甲状腺球蛋白自发产生的自身抗体的抗独特型抗体的体外和体内效应
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The transfer of immunological tolerance with tolerant lymphocytes.用耐受淋巴细胞转移免疫耐受性。
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Lymphocyte migration between mutually tolerant parabiotic rats.相互耐受的联体大鼠之间的淋巴细胞迁移。
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Regulation of experimental allergic thyroiditis.实验性变应性甲状腺炎的调节
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6
Acquisition of immunological self-recognition by the fetal rat.胎鼠免疫自我识别的获得
Immunology. 1988 Jun;64(2):319-23.
7
Interception of the development of self tolerance in fetal lambs.
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