Sarkar N K, Shankar S, Tyagi A K
Department of Biochemistry, University of Delhi South Campus, New Delhi, India.
Biochem Mol Biol Int. 1995 May;35(6):1189-98.
We have used purified RNA polymerase from Mycobacterium phlei to study the role of polyamines in mycobacterial transcription. Both initiation and elongation phases of the process were affected biphasically by polyamines. Interaction of polyamines with DNA template plays an important role in transcription modulation. Our studies emphasize that polyamines can exert a regulatory control on mycobacterial transcription.
我们使用了来自草分枝杆菌的纯化RNA聚合酶来研究多胺在分枝杆菌转录中的作用。该过程的起始和延伸阶段均受到多胺的双相影响。多胺与DNA模板的相互作用在转录调控中起着重要作用。我们的研究强调多胺可以对分枝杆菌转录施加调控。
