Schwartz R S
University of Washington School of Medicine, Division of Gerontology and Geriatric Medicine, Harborview Medical Center, Seattle, USA.
J Gerontol A Biol Sci Med Sci. 1995 Nov;50 Spec No:151-6. doi: 10.1093/gerona/50a.special_issue.151.
Many of the changes in body composition associated with aging are similar to those found in states of growth hormone deficiency. Elderly people have also been found to have significant abnormalities in several trophic factor systems including growth hormone/insulin-like growth factors, and both male and female sex hormones. This has led to intense interest in the clinical effects of trophic factor supplementation in older individuals. This article reviews the age-related alterations in the growth hormone and sex steroid axes, as well as the effects of supplementation. In addition, important questions about the use of trophic factors in the elderly that must be addressed in future research are put forth.
许多与衰老相关的身体成分变化与生长激素缺乏状态下的变化相似。研究还发现，老年人在包括生长激素/胰岛素样生长因子以及雄性和雌性性激素在内的多个营养因子系统中存在显著异常。这引发了人们对营养因子补充剂对老年人临床效果的浓厚兴趣。本文综述了生长激素和性类固醇轴的年龄相关变化以及补充剂的作用。此外，还提出了一些关于老年人使用营养因子的重要问题，这些问题有待未来研究加以解决。
