[新城疫病毒强毒株和无毒株在鸡胚成纤维细胞培养物中增殖时多肽组成的差异]

[Differences in the polypeptide composition of virulent and avirulent strains of Newcastle disease virus in reproduction in chick embryo fibroblast culture].

作者信息

Vovk T S, Kaverin N V

出版信息

Vopr Virusol. 1978 Jul-Aug(4):403-10.

Abstract

The loss of the capacity for secondary infection of the cells in reproduction of avirulent Newcastle disease virus strains in chick embryo fibroblast cultures was found. This loss was shown to be associated with changes in the polypeptide composition of the virions. In virions of the avirulent Queensland strain incapable of infection CEF cultures an additional polypeptide was found with molecular mass of 67,000 daltons which was lacking in virions of the virulent Beaudette strain and corresponded to F0 protein of paramyxoviruses.

摘要

发现在鸡胚成纤维细胞培养物中无致病性新城疫病毒株繁殖时细胞二次感染能力丧失。这种丧失与病毒粒子多肽组成的变化有关。在不能感染鸡胚成纤维细胞培养物的无致病性昆士兰毒株的病毒粒子中，发现了一种分子量为67,000道尔顿的额外多肽，而致病性博德特毒株的病毒粒子中没有这种多肽，且该多肽与副粘病毒的F0蛋白相对应。