Grigis A, Farina C, Moioli F, Parea M, Cirillo D M, Goglio A, Marchiaro G
Servizio di Microbiologia, Ospedali Riuniti, Bergamo, Italy.
Eur J Epidemiol. 1995 Jun;11(3):339-44. doi: 10.1007/BF01719440.
During the 1989 calendar year, P. aeruginosa caused clinical infections in 0.46% of patients admitted to Ospedali Riuniti (a general hospital), Bergamo, Italy. Strains (n = 267) of P. aeruginosa were collected during this period, and epidemiological characteristics were studied. The mean prevalence of P. aeruginosa infection in inpatients was 1.1% (range 0.06-7.3), whereas outpatients showed a significantly lower prevalence of infection (0.05%). Strains were recovered from inpatients of surgical wards (n = 126; 47.2%), and outpatients (n = 15; 5.6%). Males were more often affected than females (2.7:1). Infection of the urinary tract was the most common (34.1%). Pseudomonas aeruginosa was also involved in lower respiratory tract infections (18.7%) and septicaemia (17.6%). Four typing methods were performed, i.e. serotyping, antibiotyping, pyocin typing, and restriction endonuclease analysis (REA). Serotypes O:11 and O:6 were endemic in the hospital. Some serotypes correlated with specific clinical wards. Pyocin typing was an unreliable epidemiological tool. However, antibiotyping showed the presence of some epidemic clusters, probably related to the antibiotic consumption of the patients. REA suggested the circulation of edemic P. aeruginosa strains in both the obstetrics and neurosurgery wards.
在1989历年期间，铜绿假单胞菌在意大利贝加莫奥spedali Riuniti（一家综合医院）收治的患者中引起临床感染的比例为0.46%。在此期间收集了267株铜绿假单胞菌菌株，并对其流行病学特征进行了研究。住院患者中铜绿假单胞菌感染的平均患病率为1.1%（范围为0.06 - 7.3），而门诊患者的感染患病率显著较低（0.05%）。菌株从外科病房的住院患者（n = 126；47.2%）和门诊患者（n = 15；5.6%）中分离得到。男性比女性更容易受到感染（比例为2.7:1）。尿路感染是最常见的感染类型（34.1%）。铜绿假单胞菌还与下呼吸道感染（18.7%）和败血症（17.6%）有关。采用了四种分型方法，即血清分型、抗生素分型、绿脓菌素分型和限制性内切酶分析（REA）。O:11和O:6血清型在医院中呈地方性流行。一些血清型与特定临床病房相关。绿脓菌素分型是一种不可靠的流行病学工具。然而，抗生素分型显示存在一些流行集群，可能与患者的抗生素使用情况有关。REA表明在产科和神经外科病房均有地方性铜绿假单胞菌菌株的传播。
