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爱泼斯坦-巴尔病毒诱导重组激活基因RAG1和RAG2

Epstein-Barr virus induction of recombinase-activating genes RAG1 and RAG2.

作者信息

Srinivas S K, Sixbey J W

机构信息

Department of Infectious Diseases and Virology, St. Jude's Children's Research Hospital, Memphis, Tennessee 38101-0318, USA.

出版信息

J Virol. 1995 Dec;69(12):8155-8. doi: 10.1128/JVI.69.12.8155-8158.1995.

DOI:10.1128/JVI.69.12.8155-8158.1995
PMID:7494341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189773/
Abstract

In experimental B-cell infections, Epstein-Barr virus induced sustained expression of V(D)J recombinase-activating genes RAG1 and RAG2, whose aberrant activity has been implicated in chromosomal translocations in B-cell neoplasms. In cell lines in which RAG1 and RAG2 were detected, virus integrated into cellular DNA rather than assumed the configuration of extrachromosomal episomes. Expression of the Epstein-Barr virus nuclear antigen 1 in transient transfection assays was sufficient to induce both recombinase-activating genes.

摘要

在实验性B细胞感染中，爱泼斯坦-巴尔病毒诱导V(D)J重组酶激活基因RAG1和RAG2持续表达，其异常活性与B细胞肿瘤中的染色体易位有关。在检测到RAG1和RAG2的细胞系中，病毒整合到细胞DNA中，而不是呈染色体外附加体的构型。在瞬时转染试验中，爱泼斯坦-巴尔病毒核抗原1的表达足以诱导这两种重组酶激活基因。

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Epstein-Barr virus nuclear proteins EBNA-3A and EBNA-3C are essential for B-lymphocyte growth transformation.爱泼斯坦-巴尔病毒核蛋白EBNA-3A和EBNA-3C对B淋巴细胞生长转化至关重要。
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Association between the p170 form of human topoisomerase II and progeny viral DNA in cells infected with herpes simplex virus type 1.人类拓扑异构酶II的p170形式与单纯疱疹病毒1型感染细胞中病毒子代DNA之间的关联
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BCL2 translocation frequency rises with age in humans.在人类中，BCL2易位频率随年龄增长而升高。
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Expression of recombination activating genes (RAG-1 and RAG-2) in Epstein-Barr virus-bearing B cells.重组激活基因（RAG-1和RAG-2）在携带爱泼斯坦-巴尔病毒的B细胞中的表达。
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