爱泼斯坦-巴尔病毒诱导重组激活基因RAG1和RAG2
Epstein-Barr virus induction of recombinase-activating genes RAG1 and RAG2.
作者信息
Srinivas S K, Sixbey J W
机构信息
Department of Infectious Diseases and Virology, St. Jude's Children's Research Hospital, Memphis, Tennessee 38101-0318, USA.
出版信息
J Virol. 1995 Dec;69(12):8155-8. doi: 10.1128/JVI.69.12.8155-8158.1995.
Abstract
In experimental B-cell infections, Epstein-Barr virus induced sustained expression of V(D)J recombinase-activating genes RAG1 and RAG2, whose aberrant activity has been implicated in chromosomal translocations in B-cell neoplasms. In cell lines in which RAG1 and RAG2 were detected, virus integrated into cellular DNA rather than assumed the configuration of extrachromosomal episomes. Expression of the Epstein-Barr virus nuclear antigen 1 in transient transfection assays was sufficient to induce both recombinase-activating genes.
摘要
在实验性B细胞感染中，爱泼斯坦-巴尔病毒诱导V(D)J重组酶激活基因RAG1和RAG2持续表达，其异常活性与B细胞肿瘤中的染色体易位有关。在检测到RAG1和RAG2的细胞系中，病毒整合到细胞DNA中，而不是呈染色体外附加体的构型。在瞬时转染试验中，爱泼斯坦-巴尔病毒核抗原1的表达足以诱导这两种重组酶激活基因。
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