Duplication of the blood glucose curve of an OGTT in dogs by a prospectively programmed I.V. infusion: infusion pattern and IRI response.

In conscious dogs the peripheral venous blood glucose profile of an OGTT (1.0 g/kg) was individually duplicated by a computed i.v. glucose infusion. The correspondence reached between both tests was demonstrated by the correlation between the paired increments of the reactive blood glucose concentration areas. The average total dose needed for duplication was 0.52 +/-0.04 g/kg (no. = 11). There was a more rapid and greater IRI increase in OGTT than in the infusion test. When 1.0 g glucose per kg was given according to the same pattern by a computed infusion, the integrated areas both of blood glucose and of IRI was twice that in OGTT. We concluded that the IRI increase in OGTT reinforced by enteral mechanisms favors the direct hepatic uptake of absorbed glucose. This could also protect the body from an excessive insulin release provoked by the entire oral load if it reached the peripheral circulation.