Fischer U, Freyse E J, Salzsieder E, Albrecht G
Acta Diabetol Lat. 1978 Sep-Dec;15(5-6):294-302. doi: 10.1007/BF02590753.
In conscious dogs the peripheral venous blood glucose profile of an OGTT (1.0 g/kg) was individually duplicated by a computed i.v. glucose infusion. The correspondence reached between both tests was demonstrated by the correlation between the paired increments of the reactive blood glucose concentration areas. The average total dose needed for duplication was 0.52 +/-0.04 g/kg (no. = 11). There was a more rapid and greater IRI increase in OGTT than in the infusion test. When 1.0 g glucose per kg was given according to the same pattern by a computed infusion, the integrated areas both of blood glucose and of IRI was twice that in OGTT. We concluded that the IRI increase in OGTT reinforced by enteral mechanisms favors the direct hepatic uptake of absorbed glucose. This could also protect the body from an excessive insulin release provoked by the entire oral load if it reached the peripheral circulation.
在清醒犬中，通过计算机控制的静脉输注葡萄糖，可单独复制口服葡萄糖耐量试验（1.0 g/kg）的外周静脉血糖曲线。通过反应性血糖浓度区域的配对增量之间的相关性，证明了两种试验之间的一致性。复制所需的平均总剂量为0.52±0.04 g/kg（n = 11）。口服葡萄糖耐量试验中IRI的增加比输注试验更快、更大。当按照相同模式通过计算机控制的输注给予每千克1.0 g葡萄糖时，血糖和IRI的积分面积是口服葡萄糖耐量试验中的两倍。我们得出结论，肠道机制增强的口服葡萄糖耐量试验中IRI的增加有利于肝脏直接摄取吸收的葡萄糖。如果整个口服负荷进入外周循环，这也可以保护身体免受过度胰岛素释放的影响。
