Theron A J, Jooné G K, Anderson R
Department of Immunology, University of Pretoria.
S Afr Med J. 1994 Nov;84(11):743-6.
We compared the composition and opsonic activities for two common microbial pathogens (Staphylococcus aureus and Streptococcus pyogenes) of various imported intravenous (IV) (Sandoglobulin, Octagam and Gammagard) and intramuscular (IM) (Beriglobin and Globuman Berna) immunoglobulin (Ig) preparations with those of the corresponding locally manufactured products, Polygam (IV) and Intragam (IM). When tested at equivalent concentrations (1 g/100 ml) the total IgG and IgG subclass concentrations of the various IV and IM preparations were similar. All the test preparations (IV and IM) possessed similar opsonic activity for S. aureus and S. pyogenes. These findings demonstrate that, in respect of IgG content and protective biological activity, Intragam and Polygam, the locally manufactured IM and IV Ig preparations, respectively, compared extremely favourably with the corresponding imported products.
我们比较了多种进口静脉注射（IV）（Sandoglobulin、Octagam和Gammagard）和肌肉注射（IM）（Beriglobin和Globuman Berna）免疫球蛋白（Ig）制剂针对两种常见微生物病原体（金黄色葡萄球菌和化脓性链球菌）的组成和调理活性，并与相应的本地生产产品Polygam（IV）和Intragam（IM）进行了比较。当在等效浓度（1 g/100 ml）下进行测试时，各种IV和IM制剂的总IgG和IgG亚类浓度相似。所有测试制剂（IV和IM）对金黄色葡萄球菌和化脓性链球菌均具有相似的调理活性。这些发现表明，就IgG含量和保护性生物活性而言，本地生产的IM和IV Ig制剂Intragam和Polygam分别与相应的进口产品相比具有极大优势。
