van Furth R, Braat A G, Leijh P C, Gardi A
Department of Infectious Diseases, University Hospital, Leiden, The Netherlands.
Vox Sang. 1987;53(2):70-5. doi: 10.1111/j.1423-0410.1987.tb04921.x.
The composition and opsonizing activity of five commercially available immunoglobulin preparations for intravenous use (Venoglobulin I, Venilon, Gammagard, Polyglobin, and Sandoglobulin) were studied. The composition of these preparations does not differ very much as far as total protein, immunoglobulin class and IgG subclass concentrations are concerned. The only exceptions were that Veniglobulin I, Gammagard and Sandoglobulin contain IgA, which might cause side effects in patients with anti-IgA antibodies, Gammagard contains very little IgG4, and Venilon and Polyglobin contain no and almost no IgG3, respectively, which might explain their very low opsonic activity. It was found that Venilon and Gammagard activate complement in the ready-for-infusion state. The opsonic activity of Venoglobulin I, Sandoglobulin and Gammagard is about equal to that of inactivated serum: Staphylococcus aureus, Escherichia coli with K antigen, Streptococcus pyogenes and Streptococcus group B are well opsonized and E. coli without K antigen and Streptococcus pneumoniae are poorly opsonized.
对五种市售静脉注射用免疫球蛋白制剂（静脉注射用免疫球蛋白I、维尼隆、伽玛莱士、多球蛋白和沙格司亭）的组成和调理活性进行了研究。就总蛋白、免疫球蛋白类别和IgG亚类浓度而言，这些制剂的组成差异不大。唯一的例外是静脉注射用免疫球蛋白I、伽玛莱士和沙格司亭含有IgA，这可能会在具有抗IgA抗体的患者中引起副作用；伽玛莱士含有极少的IgG4；维尼隆和多球蛋白分别不含和几乎不含IgG3，这可能解释了它们极低的调理活性。研究发现，维尼隆和伽玛莱士在即将输注的状态下激活补体。静脉注射用免疫球蛋白I、沙格司亭和伽玛莱士的调理活性约等于灭活血清：金黄色葡萄球菌、带有K抗原的大肠杆菌、化脓性链球菌和B族链球菌被良好调理，而无K抗原的大肠杆菌和肺炎链球菌则调理不佳。
