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[西拉普利对稳定型动脉高血压患者疗效的评估（一项随机研究）]

[The evaluation of cilazapril efficacy in patients with stable arterial hypertension (a randomized study)].

作者信息

Belousov Iu B, Akhadov Sh V, Leonova M V, Volkov M G

出版信息

Ter Arkh. 1995;67(9):53-6.

PMID:7495044
Abstract

34 patients with stable arterial hypertension (AH) were randomized by mean arterial pressure (MAP), end-diastolic LV volume and cardiac output in a study of cilazapril efficacy in a dose 2.5 and 5 mg/day. Antihypertensive effect in the majority of patients with MAP 120-135 and 136-150 mm Hg was insufficient (diastolic pressure > 94 mm Hg). Dose-effect action on hemodynamics was absent. Hemodynamic benefits were noted in patients with end diastolic LV volume > 5.0-5.7 cm.

摘要

在一项关于西拉普利疗效的研究中，34例稳定型动脉高血压（AH）患者按平均动脉压（MAP）、舒张末期左心室容积和心输出量进行随机分组，给予2.5毫克/天和5毫克/天的剂量。大多数MAP为120 - 135毫米汞柱和136 - 150毫米汞柱的患者降压效果不足（舒张压> 94毫米汞柱）。对血流动力学不存在剂量效应作用。舒张末期左心室容积> 5.0 - 5.7厘米的患者出现了血流动力学益处。

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