Goto M, Kato Y
Division of Rheumatic Diseases, Tokyo Metropolitan Otsuka Hospital, Japan.
Thromb Haemost. 1995 Apr;73(4):576-8.
To assess the risk factors for atherosclerosis in Werner's syndrome (WS), coagulation/fibrinolytic system parameters and lipid levels were investigated in 9 non-smoker patients with WS and compared with normal control values (N). The levels of thrombin antithrombin III complex (p < 0.05), D-dimer (p < 0.05), tissue plasminogen activator (p < 0.005) and PA inhibitor 1 (p < 0.01) were significantly increased, while the level of thrombomodulin (p < 0.005) in the fasting plasma was significantly decreased in the WS cases compared with N. Lipid profiles confirmed that 8 of the 9 patients were of hyperlipidemia type IIb, 7 had hyperinsulinemia and 5 fulfilled the criteria for clinical diabetes mellitus. The hypercoagulable condition suggested the existence of multiple risk factors for atherosclerosis in WS in addition to the previously reported hyperinsulinemia and hyperlipidemia.
为评估沃纳综合征（WS）患者动脉粥样硬化的危险因素，对9例不吸烟的WS患者的凝血/纤溶系统参数和血脂水平进行了研究，并与正常对照值（N）进行比较。与N相比，WS患者空腹血浆中凝血酶 - 抗凝血酶III复合物水平（p < 0.05）、D - 二聚体水平（p < 0.05）、组织纤溶酶原激活物水平（p < 0.005）和PA抑制剂1水平（p < 0.01）显著升高，而血栓调节蛋白水平（p < 0.005）显著降低。血脂谱证实，9例患者中有8例为IIb型高脂血症，7例有高胰岛素血症，5例符合临床糖尿病标准。这种高凝状态表明，除了先前报道的高胰岛素血症和高脂血症外，WS患者还存在多种动脉粥样硬化危险因素。
