Kario K, Narita N, Matsuo T, Kayaba K, Tsutsumi A, Matsuo M, Miyata T, Shimada K
Department of Internal Medicine, Awaji-Hokudan Public Clinic, Hyogo, Japan.
Thromb Haemost. 1995 Apr;73(4):617-22.
We investigated the frequency of the factor VII Gln353 (FVII Gln353) allele in Japan, where coronary artery disease is much less common and factor VII coagulant activity (FVIIc) is lower than in Western countries. Japanese males (n = 144) aged 40-59 years living in 2 different districts were studied, and the FVIIc and activated factor VII (FVIIa) levels were measured with human (FVIIa Hum) and bovine soluble tissue factor (FVIIa Bov). The frequency of the FVII Gln353 allele in the 2 districts was 0.026 and 0.052 (combined: 0.034), which was about one third of that in a European population. Thus, the lower FVIIc level in Japanese is not due to the effect of FVII Gln353 allele. Ten individuals with the Gln353 allele showed a 39% decrease of FVIIa Hum levels and a 29% decrease of the FVIIa Bov level compared with 134 individuals homozygous for the FVII Arg353 allele. These decreases of FVIIa were greater than the decrease of FVIIc (17%), suggesting that FVII Gln353 may be difficult to activate in vivo. The marked decrease of FVIIa levels in individuals with the FVII Gln353 allele suggests that they are genetically protected against cardiovascular disease irrespective of ethnic background, by virtue of their decreased FVIIa level.
我们调查了日本人群中凝血因子VII谷氨酰胺353（FVII Gln353）等位基因的频率，在日本，冠状动脉疾病的发病率远低于西方国家，且凝血因子VII促凝活性（FVIIc）也低于西方国家。我们对居住在两个不同地区的144名40 - 59岁的日本男性进行了研究，分别用人源（FVIIa Hum）和牛源可溶性组织因子（FVIIa Bov）测定FVIIc和活化凝血因子VII（FVIIa）水平。这两个地区FVII Gln353等位基因的频率分别为0.026和0.052（合并后为0.034），约为欧洲人群的三分之一。因此，日本人较低的FVIIc水平并非由FVII Gln353等位基因的影响所致。与134名FVII精氨酸353（FVII Arg353）等位基因纯合个体相比，10名携带Gln353等位基因的个体FVIIa Hum水平降低了39%，FVIIa Bov水平降低了29%。FVIIa的这些降低幅度大于FVIIc的降低幅度（17%），这表明FVII Gln35可能在体内难以被激活。携带FVII Gln353等位基因个体的FVIIa水平显著降低，这表明无论种族背景如何，他们都因其降低的FVIIa水平而在遗传上对心血管疾病具有保护作用。
