Kario K, Matsuo T, Miyata T
Department of Internal Medicine, Awaji-Hokudan Public Clinic, Hyogo.
Rinsho Byori. 1995 Dec;43(12):1201-8.
Factor VII (FVII) is a plasma vitamin K-dependent glycoprotein that plays an important role in the initiation of tissue factor-induced coagulation (extrinsic pathway of blood coagulation). An increase in FVII coagulant activity (FVIIc) has been proposed as an independent risk factor for coronary artery disease. Recently, the coagulation assay using soluble tissue factor(sTF) enables us to measure the plasma levels of the activated form of factor VII(FVIIa) without the effect of the FVII zymogen form. We have developed the fluorogenic assay for FVIIa using sTF and measured the plasma FVIIa in atherosclerotic diseases. The FVIIa level in the Japanese was lower than that reported in Caucasians, suggesting that the incidence of ishemic heart disease is lower in the former. The FVIIa level was higher in the patients with cardiovascular diseases (ischemic heart disease and cerebral infarction), non-insulin-dependent diabetic mellitus, hypertension with microalbuminuria, and renal failure than in the healthy controls. The FVIIa levels were also increased in non-insulin-dependent diabetic patients, and this FVIIa increase was positively correlated with urinary albumin excretion. Furthermore, FVIIa levels were not correlated with the levels of lipids and the activity of hepatic synthesis, indicating that FVIIa may be an independent risk factor for cardiovascular disease.
凝血因子 VII（FVII）是一种血浆维生素 K 依赖糖蛋白，在组织因子诱导的凝血起始过程（凝血的外源性途径）中起重要作用。FVII 凝血活性（FVIIc）升高已被认为是冠状动脉疾病的独立危险因素。最近，使用可溶性组织因子（sTF）的凝血测定法使我们能够在不受 FVII 酶原形式影响的情况下测量活化形式的因子 VII（FVIIa）的血浆水平。我们已经开发出使用 sTF 的 FVIIa 荧光测定法，并测量了动脉粥样硬化疾病中的血浆 FVIIa。日本人的 FVIIa 水平低于高加索人报道的水平，这表明前者缺血性心脏病的发病率较低。心血管疾病（缺血性心脏病和脑梗死）、非胰岛素依赖型糖尿病、伴有微量白蛋白尿的高血压和肾衰竭患者的 FVIIa 水平高于健康对照组。非胰岛素依赖型糖尿病患者的 FVIIa 水平也升高，并且这种 FVIIa 升高与尿白蛋白排泄呈正相关。此外，FVIIa 水平与血脂水平和肝脏合成活性无关，表明 FVIIa 可能是心血管疾病的独立危险因素。
