Andreozzi G M, Riggio F, Buttò G, Barresi M, Leone A, Pennisi G, Martini R, Signorelli S S
Department of Internal Medicine, A. Francaviglia Chair of Angiology, University of Catania, Italy.
Angiology. 1995 Dec;46(12):1097-102. doi: 10.1177/000331979504601204.
The authors performed a retrospective study on a data base of 525 patients with peripheral arterial disease, to analyze the pathophysiologic meaning of resting transcutaneous pressure of carbon dioxide (PCO2) and of CO2 production during three minutes of local ischemia. The resting and postischemic PCO2 and its maximum increase related to rest (PCO2 production) were measured with Kontron 7640 equipment. The results show a significant increase of PCO2 production in the Fontaine stage 2A (183 patients, 4.61 mmHg, P < 0.0001), in stage 2B (194 patients, 5.22 mmHg, P < 0.0001), in the third stage (83 patients, 6.10 mmHg, P < 0.0001), and in the fourth stage (53 patients, 8.66 mmHg, P < 0.0001). Only the patients at the first stage showed an insignificant increase, perhaps because of the small number (12) in this group. The authors feel that the measurement of tcPCO2 production during local ischemic stress can be a very important parameter for evaluating peripheral arterial disease as an expression of metabolic tissue performance and, overall, of the tissue resistance to ischemia.
作者对525例外周动脉疾病患者的数据库进行了一项回顾性研究，以分析静息经皮二氧化碳分压（PCO2）及局部缺血三分钟期间二氧化碳生成量的病理生理意义。使用康强7640设备测量静息及缺血后PCO2及其相对于静息时的最大增加值（PCO2生成量）。结果显示，在Fontaine 2A期（183例患者，4.61 mmHg，P < 0.0001）、2B期（194例患者，5.22 mmHg，P < 0.0001）、三期（83例患者，6.10 mmHg，P < 0.0001）及四期（53例患者，8.66 mmHg，P < 0.0001）中，PCO2生成量均显著增加。只有一期患者的增加不显著，可能是因为该组人数较少（12例）。作者认为，局部缺血应激期间tcPCO2生成量的测量可能是评估外周动脉疾病的一个非常重要的参数，可作为代谢组织功能的一种表达，总体而言，也是组织对缺血耐受性的表达。
