Hofmann T, Wolf G, Koidl B
HNO-Universitätsklinik der Karl Franzens Universität Graz.
Laryngorhinootologie. 1995 Sep;74(9):564-7. doi: 10.1055/s-2007-997803.
We investigated the influence of four nasal decongestants and one preservative on ciliated cells, using cell cultures of human nasal mucosa. These cells were exposed to nasal decongestants in vitro. A fast decrease in ciliary beat frequency was seen during naphazoline and oxymethazoline application which was fully reversible after naphazoline. There was only a minimal decrease in ciliary beat frequency during application of phenylephrine and xylomethazoline decongestants. The preservative benzalkoniumchloride caused an irreversible decrease in ciliary beat frequency which was concentration dependent. We therefore recommend nasal decongestants which contain xylomethazoline or phenylephrine. If the preservative benzalkoniumchloride can not be substituted by newer less harmful substances, it should be added in minimal concentrations.
我们使用人鼻黏膜细胞培养物，研究了四种鼻减充血剂和一种防腐剂对纤毛细胞的影响。这些细胞在体外暴露于鼻减充血剂。在应用萘甲唑啉和羟甲唑啉期间，可见纤毛摆动频率迅速下降，在萘甲唑啉应用后完全可逆。在应用去氧肾上腺素和赛洛唑啉减充血剂期间，纤毛摆动频率仅略有下降。防腐剂苯扎氯铵导致纤毛摆动频率不可逆下降，且呈浓度依赖性。因此，我们推荐含有赛洛唑啉或去氧肾上腺素的鼻减充血剂。如果防腐剂苯扎氯铵不能被危害较小的新型物质替代，则应添加最低浓度。
