一些四亚甲基噻吩并[2,3-d]嘧啶衍生物的合成及抗菌活性
Synthesis and antimicrobial activity of some tetramethylenethieno[2,3-d]pyrimidine derivatives.
作者信息
Ismail K A, Aboulwafa O M, Koreish E A
机构信息
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
出版信息
Farmaco. 1995 Sep;50(9):611-6.
A series of tetramethylenethieno[2,3-d]pyrimidine derivatives has been synthesized and tested for its antimicrobial properties. All the synthesized compounds were found to exhibit in vitro antibacterial and/or antifungal activity. The highest activity was elicited by 4-benzolhydrazino-5,6-tetramethylenethieno[2,3-d]pyrimidine (9) showing MIC value of 7.81 micrograms/ml against E. Coli and C. albicans, while its MBC value was half that of nystatin. Compound 16 was almost as potent as nystatin exhibiting a minimum bactericidal concentration (MBC) value of 15.62 micrograms/ml.
已经合成了一系列四亚甲基噻吩并[2,3 - d]嘧啶衍生物，并对其抗菌性能进行了测试。发现所有合成的化合物都表现出体外抗菌和/或抗真菌活性。4 - 苯甲酰肼基 - 5,6 - 四亚甲基噻吩并[2,3 - d]嘧啶（9）表现出最高活性，对大肠杆菌和白色念珠菌的最低抑菌浓度（MIC）值为7.81微克/毫升，而其最低杀菌浓度（MBC）值是制霉菌素的一半。化合物16几乎与制霉菌素一样有效，最低杀菌浓度（MBC）值为15.62微克/毫升。
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