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新型噻唑并[4,5-d]嘧啶衍生物的合成用于抗菌、抗HIV及抗癌研究。

Synthesis of novel thiazolo[4,5-d]pyrimidine derivatives for antimicrobial, anti-HIV and anticancer investigation.

作者信息

Rida S M, Habib N S, Badawey E A, Fahmy H T, Ghozlan H A

机构信息

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.

出版信息

Pharmazie. 1996 Dec;51(12):927-31.

PMID:8985982
Abstract

Some novel thiazolo[4,5-d]pyrimidines containing 6-arylideneamino (3a-e). 2-dicyanomethylidene (5a), 2-(cyanoethoxy carbonyl) methylidene (5b) or 2-hydrazono (7a, b) moieties were synthesized. The prepared compounds were tested in vitro for their antibacterial, antifungal, anti-HIV and anticancer activities. Most of them showed promising antifungal activity, but only a few compounds exhibited anticancer activity.

摘要

一些含有6-亚芳基氨基（3a - e）、2-二氰基亚甲基（5a）、2-（氰基乙氧基羰基）亚甲基（5b）或2-腙基（7a，b）部分的新型噻唑并[4,5 - d]嘧啶已被合成。所制备的化合物进行了体外抗菌、抗真菌、抗HIV和抗癌活性测试。其中大多数显示出有前景的抗真菌活性，但只有少数化合物表现出抗癌活性。

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