Thompson M J, Elton R A, Sturgeon K R, Manclark S L, Fraser A K, Walker W S, Cameron E W
Department of Cardiothoracic Surgery, Royal Infirmary, Edinburgh, UK.
Eur J Cardiothorac Surg. 1995;9(8):419-25. doi: 10.1016/s1010-7940(05)80076-4.
Predictors of outcome in long-stay patients following cardiac surgery have hitherto been ill defined. The aims of this study were to test the Parsonnet pre-operative scoring system and to define a scoring system for inhospital mortality applicable post-operatively to strengthen the clinical decision-making process. Following case note review of 262 consecutive patients who stayed 7 days or more in intensive care, a total of 110 pre-, intra- and post-operative factors were documented. In this long-stay group the Parsonnet score was confirmed to be predictive of 30 day mortality. Univariate analysis identified significant association between mortality in the Intensive Care Unit (ICU) and the following: inotrope days, (defined as number of inotropes times number of days) ventilation, units of platelets (P = < 0.00001), chest reopening, fresh frozen plasma units (P < 0.002), total parenteral nutrition, noradrenaline, Parsonnet score (P = 0.005), dopamine, bypass time, vasodilators, intra-aortic balloon counterpulsation, enteral nutrition and other major surgery (P < 0.05). Stepwise logistic regression on these significant factors was used to produce the Edinburgh Cardiac Surgery Score (ECS) applicable from Day 10 onwards in the intensive care unit: ECS Score = (Inotrope days) +2 (Ventilation) + (Platelets) + (Parsonnet) -3. The ECS score may be a useful predictor of ICU mortality probability for cardiac surgical patients requiring 10 days or more intensive care and is presently undergoing prospective evaluation in our centre.
心脏手术后长期住院患者的预后预测因素迄今尚未明确界定。本研究的目的是检验帕森内特术前评分系统,并确定一个术后适用于住院死亡率的评分系统,以加强临床决策过程。在对262例在重症监护室连续住院7天或更长时间的患者进行病例记录回顾后,共记录了110个术前、术中和术后因素。在这个长期住院组中,帕森内特评分被证实可预测30天死亡率。单因素分析确定重症监护病房(ICU)死亡率与以下因素之间存在显著关联:血管活性药物使用天数(定义为血管活性药物数量乘以使用天数)、通气、血小板单位(P = < 0.00001)、再次开胸、新鲜冰冻血浆单位(P < 0.002)、全胃肠外营养、去甲肾上腺素、帕森内特评分(P = 0.005)、多巴胺、体外循环时间、血管扩张剂、主动脉内球囊反搏、肠内营养和其他大手术(P < 0.05)。对这些显著因素进行逐步逻辑回归分析,得出了从重症监护室第10天起适用的爱丁堡心脏手术评分(ECS):ECS评分 =(血管活性药物使用天数)+2(通气)+(血小板)+(帕森内特评分)-3。对于需要10天或更长时间重症监护的心脏手术患者,ECS评分可能是ICU死亡率概率的一个有用预测指标,目前正在我们中心进行前瞻性评估。