Lien E A, Anker G, Ueland P M
Department of Clinical Biology, Haukeland University Hospital, Bergen, Norway.
J Steroid Biochem Mol Biol. 1995 Nov;55(2):229-31. doi: 10.1016/0960-0760(95)00169-z.
We measured the serum levels of tamoxifen and 5 of its metabolites in serum from 7 premenopausal and 9 postmenopausal women during the first 56 days of treatment. The serum levels of N-desdimethyltamoxifen were higher in postmenopausal women compared to premenopausal women (P < 0.02). A similar trend was observed for N-desmethyltamoxifen (P = 0.06).
我们测量了7名绝经前和9名绝经后女性在治疗的前56天血清中他莫昔芬及其5种代谢物的水平。绝经后女性血清中N-去甲基他莫昔芬的水平高于绝经前女性（P < 0.02）。N-去甲他莫昔芬也观察到类似趋势（P = 0.06）。
