Robinson S, Schwinn H, Josic D, Nur I, Stadler M, Bal F, Gehringer W, Schütz R
Octapharma AG, Ziegelbrücke, Switzerland.
Blood Coagul Fibrinolysis. 1995 Jul;6 Suppl 2:S40-7. doi: 10.1097/00001721-199506002-00010.
This paper describes the development of a double-virus-inactivated preparation. The original goal was to inactivate and/or remove parvovirus from plasma-derived factor VIII. More recently, attention has also been focused on the controversial issue of transmission of the non-lipid-coated hepatitis A virus by preparations of factor VIII which have been solvent/detergent-treated and purified by ion-exchange chromatography.
本文描述了一种双病毒灭活制剂的研发情况。最初的目标是从血浆源性凝血因子VIII中灭活和/或去除细小病毒。最近，人们也将注意力集中在一个有争议的问题上，即经溶剂/去污剂处理并通过离子交换色谱法纯化的凝血因子VIII制剂是否会传播非脂质包膜的甲型肝炎病毒。
