Matthew J A, Johnson I T
Institute of Food Research, Norwich Laboratory, Norwich Research Park, Colney, UK.
Eur J Cancer Prev. 1995 Oct;4(5):425-8. doi: 10.1097/00008469-199510000-00011.
A strong positive relationship between dietary intake of eggs and risk of colorectal cancer has been observed in a number of epidemiological surveys. In this study we investigated the relationship between egg consumption and intermediate biomarkers of crypt cell proliferation in the colon and rectum of 75 patients who had adenomatous polyps or no evidence of bowel disease. Biopsies of normal flat mucosa were obtained at colonoscopy, and microdissected crypts were used to measure crypt length, frequency of mitosis per crypt and spatial distribution of mitoses within the crypt. There was no significant difference in the consumption of eggs by patients with adenomatous polyps (n = 53) and those without (n = 22). There was no significant positive correlation between frequency of egg consumption and any of the parameters of crypt cell proliferation in the group as a whole, nor when the patients with polyps were analysed separately. This study provides no biological evidence of any relationship between egg consumption and abnormal cell proliferation among patients at relatively high risk of colorectal neoplasia.
在多项流行病学调查中，已观察到鸡蛋的饮食摄入量与结直肠癌风险之间存在很强的正相关关系。在本研究中，我们调查了75例患有腺瘤性息肉或无肠道疾病证据的患者的鸡蛋摄入量与结肠和直肠隐窝细胞增殖中间生物标志物之间的关系。在结肠镜检查时获取正常扁平黏膜的活检组织，并使用显微切割的隐窝来测量隐窝长度、每个隐窝的有丝分裂频率以及隐窝内有丝分裂的空间分布。患有腺瘤性息肉的患者（n = 53）和未患腺瘤性息肉的患者（n = 22）在鸡蛋摄入量方面没有显著差异。在整个研究组中，鸡蛋摄入频率与隐窝细胞增殖的任何参数之间均无显著正相关，对患有息肉的患者单独分析时也是如此。本研究没有提供任何生物学证据表明在结直肠肿瘤发生风险相对较高的患者中，鸡蛋摄入与异常细胞增殖之间存在任何关系。
