Cantone M C, De Bartolo D, Giussani A, Ottolenghi A, Nüsslin F, Hansen C, Roth P, Werner E
Università degli Studi di Milano, Diparimento di Fisica, Sezione di Fisica Medica, Italy.
Appl Radiat Isot. 1995 Oct;46(10):987-90. doi: 10.1016/0969-8043(95)00202-o.
The combination of analytical techniques such as PNA and SIMS with a compartmental approach enables the study of the metabolism and biokinetics in humans of several elements by using stable isotopes as tracers. The techniques developed for Te require the administration of greater masses than those used for similar studies performed with radioactive tracers, therefore a test was carried out in rabbits in order to assess the possible influence of the administered amounts on the determination of the biokinetic parameters. The behaviour of the tracers was found to be similar for Te administration of up to 70 micrograms/kg of body weight. An inter-individual variability in the size of the transfer compartment was observed and has to be taken into account.
将诸如肽核酸（PNA）和二次离子质谱（SIMS）等分析技术与分区方法相结合，能够利用稳定同位素作为示踪剂来研究人体中多种元素的代谢和生物动力学。为碲（Te）开发的技术需要施用比使用放射性示踪剂进行类似研究时更大的质量，因此在兔子身上进行了一项试验，以评估施用量对生物动力学参数测定的可能影响。结果发现，当碲的施用量高达70微克/千克体重时，示踪剂的行为相似。观察到转移区室大小存在个体间差异，必须予以考虑。
