Martal J, De La Llosa-Hermier M P, Chêne N, Huynh L, Millet S, L'Haridon R, Assal A, Roignant N, Chaouat G
INRA Unité d'Endocrinologie de l'Embryon, Jouyen-Josas.
Contracept Fertil Sex. 1995 Sep;23(9):562-72.
Current evidence support the hypothesis that trophoblast interferons play a key role in preventing maternal immunologal rejection of the embryonic semi-allograft. The information of this review is divided in two sections. In the first section we described molecular and biological characteristics of type I (alpha, beta, omega, tau and spl) and type II (gamma) interferons. In the second section we emphasize studies on immunoendocrine functions of IFN-tau (oTP-1 or trophoblastins) in the network of cytokines and hormonal environment at the uterine embryonic interface.
目前的证据支持这样一种假说，即滋养层干扰素在防止母体对胚胎半同种异体移植物的免疫排斥中起关键作用。本综述的信息分为两个部分。在第一部分中，我们描述了I型（α、β、ω、τ和δ1）和II型（γ）干扰素的分子和生物学特性。在第二部分中，我们重点介绍了在子宫-胚胎界面的细胞因子网络和激素环境中，IFN-τ（oTP-1或滋养层蛋白）的免疫内分泌功能研究。
