血管活性肠肽和乙酰胆碱对大鼠体内阴茎勃起的影响。
Effect of vasoactive intestinal peptide and acetylcholine on penile erection in the rat in vivo.
作者信息
Suh J K, Mun K H, Cho C K, Shin H C, Kim Y S, Park T C
机构信息
Department of Urology, Yeungnam University School of Medicine, Taegu, Korea.
出版信息
Int J Impot Res. 1995 Jun;7(2):111-8.
We investigated the effect of vasoactive intestinal peptide (VIP) and its combination with acetylcholine (ACh) on the erectile response in 52 adults rats. Intracavernous injection of VIP (10(-8) to 10(-5)M, ACh (10(-9) to 10(-5), or a combination of VIP (10(-7) to 10(-5) with ACh (10(-6 M) additively enhanced that erection but did not lead to a full erection. VIP-antagonist (10(-9) to 10(-5 M), as well as atropine alone (10 (-7) to 10(-5 M), partially suppressed full erection induced by cavernous nerve stimulation (1 Hz, 3-6 V) in a dose-dependent manner, and the combination of VIP-antagonist (10(-9) to 10(-5 M) with atropine (10(-6 M) showed an additive effect. The results indicate that although VIP as well as ACh in involved in penile erection, they are not likely to be principal neurotransmitters. Their clinical application in the treatment of impotence may be confined to use in conjunction with another vasoactive agent.
我们研究了血管活性肠肽（VIP）及其与乙酰胆碱（ACh）联合应用对52只成年大鼠勃起反应的影响。海绵体内注射VIP（10^(-8)至10^(-5)M）、ACh（10^(-9)至10^(-5)）或VIP（10^(-7)至10^(-5)）与ACh（10^(-6)M）的组合可增强勃起，但不能导致完全勃起。VIP拮抗剂（10^(-9)至10^(-5)M）以及单独的阿托品（10^(-7)至10^(-5)M）以剂量依赖性方式部分抑制海绵体神经刺激（1Hz，3 - 6V）诱导的完全勃起，且VIP拮抗剂（10^(-9)至10^(-5)M）与阿托品（10^(-6)M）的组合显示出相加作用。结果表明，尽管VIP和ACh都参与阴茎勃起，但它们不太可能是主要神经递质。它们在治疗阳痿中的临床应用可能仅限于与另一种血管活性药物联合使用。
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