Sazova O, Kadioğlu A, Gürkan L, Kayaarasi Z, Bross S, Manning M, Jünemann K P
Department of Urology, Mannheim Medical Faculty, University of Heidelberg, Germany.
Int J Impot Res. 2002 Feb;14(1):44-9. doi: 10.1038/sj.ijir.3900813.
In accordance with the data reporting the identification of nitric oxide synthase (NOS) and vasoactive intestinal polypeptide (VIP) positive nerve fibres in the trabecular meshwork of the corpus cavernosum, we suggest that nitric oxide (NO) and VIP may serve complementary physiological roles in penile erection. Therefore SIN-1 and VIP were administered alone and in combination in an in vivo rabbit model. All rabbits revealed basal pressure values of 5-8 cm H2O intracavernously. In the rabbits intracavernously (i.c.) injected with SIN-1 alone and VIP alone, no adequate erectile responses were observed. Whereas, in the group intracavernously injected with the combination of SIN-1+VIP, erectile responses with mean maximal intracavernous pressure (max. ICP) 52.8 (+/-13.2) cm H2O were noted. These pressure elevations do not statistically diverge (P>0.05) than the ones obtained in the control group administered i.c. injections of the combination of papaverine/phentolamine (mean max. ICP 51 (+/-14.73) cm H2O). Referring to our results, we conclude that the combined use of SIN-1+VIP could play an important role in the physiological treatment of erectile dysfunction.
根据有关在阴茎海绵体小梁网中鉴定出一氧化氮合酶（NOS）和血管活性肠肽（VIP）阳性神经纤维的数据，我们认为一氧化氮（NO）和VIP在阴茎勃起过程中可能发挥互补的生理作用。因此，在体内兔模型中单独及联合给予SIN-1和VIP。所有兔子海绵体内的基础压力值为5-8 cm H₂O。在单独海绵体内注射SIN-1和单独注射VIP的兔子中，未观察到足够的勃起反应。然而，在海绵体内注射SIN-1+VIP组合的组中，观察到勃起反应，平均最大海绵体内压（最大ICP）为52.8（±13.2）cm H₂O。这些压力升高与海绵体内注射罂粟碱/酚妥拉明组合的对照组所获得的压力升高相比，在统计学上无差异（P>0.05）（平均最大ICP为51（±14.73）cm H₂O）。根据我们的结果，我们得出结论，SIN-1+VIP联合使用可能在勃起功能障碍的生理治疗中发挥重要作用。
