Bielicki D, Markiewski M, Wielondek M, Chosia M, Domagała W
Gastroenterology Clinic, Medical Academy, Szczecin.
Pol J Pathol. 1995;46(3):151-4.
Proliferative activity of epithelial tumor cells was evaluated with the use of immunohistochemistry and anti-PCNA monoclonal antibodies in alcohol fixed paraffin embedded sections of 44 colonic adenomas, including 33 tubular, 5 villous and 6 tubulovillous adenomas. The mean PCNA index was 24.7 +/- 10.9%, 24.8 +/- 6.2% and 24.8 +/- 14.0% in tubular, villous and tubulovillous adenomas respectively. In 12 tubular adenomas with dysplasia the mean PCNA index in areas with dysplasia was significantly higher (38.2 +/- 11.5%) as compared to areas without dysplasia (17.0 +/- 8.9%; p < 0.05). The results indicate that PCNA index of epithelial tumor cells is significantly increased in adenomas with high grade of dysplasia irrespective of histological type or size of the tumour.
采用免疫组织化学和抗增殖细胞核抗原（PCNA）单克隆抗体，在44例结肠腺瘤酒精固定石蜡包埋切片中评估上皮肿瘤细胞的增殖活性，其中包括33例管状腺瘤、5例绒毛状腺瘤和6例管状绒毛状腺瘤。管状、绒毛状和管状绒毛状腺瘤的平均PCNA指数分别为24.7±10.9%、24.8±6.2%和24.8±14.0%。在12例伴有发育异常的管状腺瘤中，发育异常区域的平均PCNA指数（38.2±11.5%）显著高于无发育异常区域（17.0±8.9%；p<0.05）。结果表明，无论肿瘤的组织学类型或大小如何，高级别发育异常的腺瘤中上皮肿瘤细胞的PCNA指数均显著升高。
