Migone N, Modena V, Daneo V, Carbonara A O, Ceppellini R
Ann Rheum Dis. 1978 Dec;37(6):513-7. doi: 10.1136/ard.37.6.513.
Among 39 patients (23 males, 16 females) with sacroiliitis (SI) 17 were HLA-B27 positive. The female/male ratio in the B27-positive group was 2/15. Seventy-four first-degree relatives of 26 probands were also investigated. A high occurrence of SI (20%) was observed in the families of B27-positive probands compared with only 3.7% in the families of B27-negative probands. In the former families SI occurred only in B27-positive subjects with an earlier onset of symptoms and a male prevalence. In the latter, the disease showed a later onset and a lack of male preponderance. The nosological and prognostic relevance of the B27 typing is stressed.
在39例骶髂关节炎（SI）患者中（男性23例，女性16例），17例HLA - B27呈阳性。B27阳性组的女性/男性比例为2/15。还对26名先证者的74名一级亲属进行了调查。与B27阴性先证者的家族中仅3.7%的发病率相比，在B27阳性先证者的家族中观察到骶髂关节炎的高发病率（20%）。在前一组家族中，骶髂关节炎仅发生在症状出现较早且以男性为主的B27阳性个体中。在后一组家族中，疾病发病较晚且无男性优势。强调了B27分型在疾病分类学和预后方面的相关性。
