[非糖尿病妊娠对果糖胺和糖化血红蛋白浓度的影响]

[Influence of non-diabetic pregnancy on fructosamine and HbA1c concentration].

作者信息

Günter H H, Ritter C, Reinhardt W, Strahl B, Niesert S, Mitzkat H J

机构信息

Zentrum Frauenheilkunde Medizinischen Hochschule Hannover.

出版信息

Z Geburtshilfe Neonatol. 1995 Jul-Aug;199(4):148-55.

PMID:7497016

Abstract

HbAIc and fructosamine concentrations were measured in the course of 177 nondiabetic pregnancies and compared with the corresponding values of 24 nondiabetic nonpregnant women. In all three trimesters HbAIc and fructosamine were significantly lower than the corresponding values in the nonpregnant women; HbAIc: 1st trimester 4.77 +/- 0.62%, 2nd trimester 4.38 +/- 0.59%, 3rd trimester 4.33 +/- 0.49%, p < 0.01; fructosamine 1st trimester 2.13 +/- 0.17 mmol/l, 2nd trimester 2.02 +/- 0.15 mmol/l, 3rd trimester 1.90 +/- 0.15 mmol/l, p < 0.01; nonpregnant women: HbAIc 5.13 +/- 0.41%, fructosamine 2.53 +/- 0.17 mmol/l. However, if the fructosamine is correlated to the respective total protein concentration a constant value results for the course of pregnancy. The changes in the HbAIc and fructosamine concentrations in pregnancy should be taken into account when treating pregnant diabetics.

摘要

在177例非糖尿病孕妇孕期测量糖化血红蛋白（HbAIc）和果糖胺浓度，并与24例非糖尿病非孕女性的相应值进行比较。在孕期的所有三个阶段，HbAIc和果糖胺均显著低于非孕女性的相应值；HbAIc：孕早期4.77±0.62%，孕中期4.38±0.59%，孕晚期4.33±0.49%，p<0.01；果糖胺：孕早期2.13±0.17 mmol/l，孕中期2.02±0.15 mmol/l，孕晚期1.90±0.15 mmol/l，p<0.01；非孕女性：HbAIc 5.13±0.41%，果糖胺2.53±0.17 mmol/l。然而，如果将果糖胺与各自的总蛋白浓度相关联，则孕期过程会得出一个恒定值。治疗妊娠糖尿病患者时应考虑孕期HbAIc和果糖胺浓度的变化。