Roberts A B, Baker J R, Court D J, James A G, Henley P, Ronayne I D
Lancet. 1983 Oct 29;2(8357):998-1000. doi: 10.1016/s0140-6736(83)90982-0.
Fructosamine, an indicator of glycosylated serum protein, was measured in 79 non-diabetic pregnant women and 20 women with gestational diabetes. The test provided a clear discrimination between groups; it detected 17 (85%) of the women with gestational diabetes and gave only 4 (5%) false-positive results. 19 women with established diabetes before pregnancy had very high levels. Maternal fructosamine at 29 weeks' gestation correlated significantly with both fasting blood glucose levels at the time and birthweight ratio. Levels of fructosamine in cord blood were significantly higher in gestational diabetic than in normal pregnancies, suggesting a possible additional role for fructosamine in retrospectively detecting the hyperglycaemic fetus. Fructosamine estimation is fully automated and may provide a simple, inexpensive means to screen for diabetes in pregnancy.
果糖胺是一种糖基化血清蛋白指标，对79名非糖尿病孕妇和20名妊娠期糖尿病妇女进行了检测。该检测能清晰地区分不同组；它检测出了17名（85%）妊娠期糖尿病妇女，假阳性结果仅4例（5%）。19名孕前已确诊糖尿病的妇女果糖胺水平非常高。孕29周时母体果糖胺与当时的空腹血糖水平及出生体重比均显著相关。妊娠期糖尿病孕妇脐带血中的果糖胺水平显著高于正常妊娠孕妇，这表明果糖胺在回顾性检测高血糖胎儿方面可能还有额外作用。果糖胺测定完全自动化，可能为孕期糖尿病筛查提供一种简单、廉价的方法。
