Oddis C V, Medsger T A
Department of Medicine, University of Pittsburgh School of Medicine, PA 15261, USA.
Baillieres Clin Rheumatol. 1995 Aug;9(3):497-514. doi: 10.1016/s0950-3579(05)80255-9.
New information regarding myositis specific autoantibodies, histopathologic analysis of muscle biopsy specimens, and immunogenetic features of the different serologic subsets of disease has greatly increased our understanding of the pathogenesis of the inflammatory myopathies. The clinical descriptions of inclusion body myositis and 'amyopathic dermatomyositis' (Euwer and Sontheimer, 1993) are examples of our expanded descriptive capabilities in the evaluation of patients with myopathy. Finally, newer techniques such as cytokine analysis and magnetic resonance imaging may help in the ongoing assessment of disease activity in patients with myositis. The combination of these recently described clinical and laboratory parameters are enough to force a reconsideration of the previously described classification and diagnostic criteria in the inflammatory myopathies.
有关肌炎特异性自身抗体、肌肉活检标本的组织病理学分析以及疾病不同血清学亚组的免疫遗传学特征的新信息，极大地增进了我们对炎性肌病发病机制的理解。包涵体肌炎和“无肌病性皮肌炎”的临床描述（Euwer和Sontheimer，1993年）是我们在评估肌病患者时扩展的描述能力的实例。最后，诸如细胞因子分析和磁共振成像等新技术可能有助于持续评估肌炎患者的疾病活动度。这些最近描述的临床和实验室参数的结合足以促使重新考虑炎性肌病中先前描述的分类和诊断标准。
