Vaubourdolle M, Chazouillères O, Briaud I, Legendre C, Serfaty L, Poupon R, Giboudeau J
Service de Biochimie A, Hôpital Saint-Antoine, Paris, France.
Clin Chem. 1995 Dec;41(12 Pt 1):1716-9.
alpha-Glutathione S-transferase (alpha-GST; EC 2.5.1.18) has been advocated as a better marker of hepatocellular damage than the transaminases in toxic and autoimmune hepatitis. We have assessed the potential interest of plasma alpha-GST determination in 94 anti-hepatitis C virus-positive patients with histologically proven chronic hepatitis C (34 women, 60 men, ages 40.0 +/- 11.9 years). Blood samples were assayed for aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase, alkaline phosphatase, and alpha-GST on the same day a liver biopsy was performed. alpha-GST concentrations were significantly above reference values in 64% of patients (compared with 58% for AST, 68% for ALT), and this increase was seen in 52% of patients with normal values for transaminases and a Knodell score > 3. Furthermore, there was a significant correlation between alpha-GST and lobular necrosis score (r = 0.31; P < 0.01). Our findings suggest that association of plasma alpha-GST with ALT may improve the biochemical assessment of liver damage in patients with chronic hepatitis C.
α-谷胱甘肽S-转移酶（α-GST；EC 2.5.1.18）被认为在毒性和自身免疫性肝炎中，是比转氨酶更好的肝细胞损伤标志物。我们评估了94例抗丙型肝炎病毒阳性且经组织学证实为慢性丙型肝炎患者（34名女性，60名男性，年龄40.0±11.9岁）血浆α-GST测定的潜在价值。在进行肝活检的同一天，对血样进行天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、γ-谷氨酰转移酶、碱性磷酸酶和α-GST检测。64%的患者α-GST浓度显著高于参考值（AST为58%，ALT为68%），在转氨酶值正常且Knodell评分>3的患者中，52%出现这种升高。此外，α-GST与小叶坏死评分之间存在显著相关性（r = 0.31；P < 0.01）。我们的研究结果表明，血浆α-GST与ALT联合检测可能会改善慢性丙型肝炎患者肝损伤的生化评估。
